Applications of Bioinformatics on Genomics and Proteomics Levels Highlighted in Brucella Pathogen

Document Type : Original Article

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Abstract

In a variety of industries, including biotechnology and medicine, bioinformatics is
extremely important. It offers an extensive range of uses in the structural and
sequencing analysis of biological data. Each application has distinct functions in data
interpretation, as database search sequence and alignment are essential tools that are
prerequisites for more advanced applications like modelling, epitope predictions, and
molecular docking. Genome annotation is thought to be the key to decoding the
meaningless sequence data and providing crucial details about the protein-coding genes
and genomic characteristics. Additionally, comparative modelling, fold modelling, and
ab initio modelling are the three main approaches to protein modelling, which is
fundamental for various proteomics applications. Epitopes prediction for B cells and T
cells using MHC I and MHCII is another significant use. This may aid in the development
of novel vaccine candidates for the prevention and management of infectious illnesses.
Software can virtually dock the created 3D model or predicted epitopes with ligand to
construct a new medicine or vaccination quickly and affordably. Using bioinformatics
tools in diagnosis and control of brucellosis has a promising vision to eliminate the
disease. 

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