Lactate Dehydrogenase and Aspartate Aminotransaminase, Activities as A Prognostic Indices to The Severity of Donkey’s Colic

Document Type : Original Article

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1 Departement of Medicine and infectious diseases, faculty of veterinary medicine, university of sadat city

2 Department of Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Egypt.

Abstract

Colic consider as one of the most and common cause leading to death in horses and donkeys. Colic is a general expression that refers to any gastrointestinal pain in horses and donkeys, our study aimed to evaluate the clinical -biochemical alterations of donkey’s colicand proves the link between aspartate aminotransaminase, lactate dehydrogenase and severity grades in colicky donkeys. Thirty-five Egyptian donkey were included in this study, these donkeys were divided into fifteen apparently clinically healthy  donkeys and twenty donkeys suffering from colic in Menofia and Behira Governate, these selected cases are clinically examined and biochemically expressed through estimation of serum glucose, total protein, blood urea nitrogen , Creatinine , Calcium , Potassium , Sodium, Alanine  aminotransaminase , Aspartate aminotransaminase, Lactate dehydrogenase, Serum Malondialdehyde  and Total antioxidant capacity. Clinical examination of the donkeys with signs of colic showed moderate significant increase in heart and respiratory rates with a great significant increase in capillary refill time. Analysed serum indicatedmild significant increase in the levels of glucose and malondialdehyde as well as great significant increase in the Aspartate aminotransaminase and lactate dehydrogenase. On the other hand, there is significant decline of calcium and potassium. In Conclusions There is a difference in some clinical variables and some serum biochemistries, so we can recommend that the correlation between activities of aspartate aminotransaminase, lactate dehydrogenase in colicky donkeys can be used as an aid in the prognosis and gauging severity of tissue damage in donkey’s colic.

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