Potential Effect of a Novel Composite (Calcium Carbonate Nanoparticles/ Silver Nanoparticles/Advanced-Platelet Rich Fibrin) on Healing of Critical Bone Defect in Rabbits: Radiographic Evaluation

Document Type : Original Article

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Department of Surgery, Radiology and Anesthesiology, Faculty of Veterinary Medicine, University of Sadat City.

Abstract

The aim of the present study was to evaluate the efficacy of calcium carbonate nanoparticles (CCNPs)/Silver nanoparticles (Ag NPs)/Advanced-PRF composite to induce new bone formation and accelerate bone regeneration when be used to fill an experimentally critical defect in radial bone of rabbits. Twenty-four adult apparently healthy New Zealand white rabbits aged from 5-to 6 months and weighing 3.5 ± 0.5 kg were used in this study and were divided into two groups, group A: was left empty as a control. Group B: we used CCNPs/AgNPs/A-PRF composite. During observation, period rabbits were observed clinically and radiographically at 2,4,8,12 weeks post-operation. Results: the radiographic finding showed a great significant difference between the two groups and the CCNPs/AgNPs/A-PRF composite could make complete healing at the end of the observation period. Conclusion: radiographical studies revealed that CCNPs/AgNPs/A-PRF composite has exalted efficacy to induce new bone formation.

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Journal of Current Veterinary Research
Volume 4, Issue 2
October 2022
Pages 104-112

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