Bioavailability Study of Cefepime After Intravenous and Intramuscular Administration in Normal Broiler Chickens

Document Type : Original Article

Authors

1 Department of pharmacology, Faculty of Vet. Med., University of Sadat City.

2 Department of biochemistry, toxicology, feed deficiency-Animal Health Research Institute- Dokki- Egypt

Abstract

The bioavailability of cefepime in normal broiler chickens was investigated after single
intramuscular and intravenous administrations at a dose of 100 mg/kg b.wt. Serum
concentrations of cefepime were determined by using high performance liquid
chromatography (HPLC). Following compartmental analysis, a two-compartment open model
best described the concentration-time data of cefepime after intramuscular and intravenous
administration. After intramuscular administration, the drug reached its maximum serum
concentrations (Cmax) of 193.06 ± 2.27 μg/ml at maximum time (Tmax) of 1.138 ± 0.012 h,
absorption half-life (t1/2ab) was 0.491 ± 0.027 h and (AUC0-t) was 1127.58 ± 14.48 μg/ml/h.
Following a single intravenous injection, the drug was detected till 24 hours, distribution
half-life (t1/2α) was 0.217 ± 0.036 h, elimination half-life (t1/2β) was of 4.608 ± 0.145 h and
clearance (CL) was 0.090 ± 0.002 (mg/kg)/(μg/ml)/h, volume of distribution at steady state
(Vdss) was 0.586 ± 0.11 (mg/kg)/(μg/ml) and bioavailability was 104.30 ± 2.34 %. Limits of
detection and quantification were 0.03 and 0.10 μg/ml, respectively.

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