A study on antiviral efficacy of Brucella abortus ether extract against experimental rabies infection in mice

Document Type : Original Article

Authors

1 Central Laboratory for Evaluation of Veterinary Biologics, Abassia Cairo, Egypt

2 Central Laboratory for Evaluation of Veterinary Biologics, Abassia Cairo.

3 Veterinary Serum and Vaccine Research Institute, Abassia Cairo.

Abstract

The present work deals with Bru-Pel extract in a trial to investigate its effect against rabies virus. The obtained results revealed that Bru-pel has the affinity to induce the highest level of interferon when inoculated 8 hours pre-exposure to rabies infection. However it has no antiviral effect against rabies virus in mice when administrated pre and post-exposure to experimental infection even on zero time. So, it could not be used as post-exposure treatment in case of rabies infection. It was preferable to use specific antiserum with rabies vaccine in emergency cases (post-exposure) for providing the highest rate of protection when administrated on the suitable time (0 to 3 days post-exposure).

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