The Efficiency of Nanohydroxyapatite Granules on Bone Regeneration: Radiographic and Histopathologic Study in a Canine Model

Gadallah, Shaaban M.; Mohamed, Mahmoud M.; Al Akraa, Adel; Sharshar, Ahmed; El‑Sunsafty, Mohamed

doi:10.21608/jcvr.2024.384910

The Efficiency of Nanohydroxyapatite Granules on Bone Regeneration: Radiographic and Histopathologic Study in a Canine Model

Document Type : Original Article

Authors

10.21608/jcvr.2024.384910

Abstract

The primary factors leading to bone loss are trauma, tumor excision, and
degeneration. Ongoing research has focused on investigating the efficacy of natural
and synthetic substitutes for bone grafts, utilizing both in vivo and in vitro
experiments. This study aimed to assess the efficacy of nano-hydroxyapatite (N-HA)
in stimulating bone regeneration in significant bone defects in the tibia of dogs. This
study utilized a cohort of 12 adult male mongrel dogs. Two holes with a diameter of
10 mm were surgically created in the upper region of the tibial bone. One defect
was filled with Nano-HA powder, while the other defect was left unfilled. The
advancement of N-HA's healing process was monitored through sequential
radiographic imaging and histological examination until the completion of each
designated observation period. The findings of our investigation demonstrated that
the region where N-HA was inserted exhibited enhanced bone formation,
suggesting a more rapid and robust healing reaction in comparison to the control
site. The data presented here provide empirical evidence supporting the notion that
Nano-HA possesses favorable biocompatibility, biodegradability, and
osteoinductive properties.

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