Prenatal Development of Rabbit Cerebellum

Elnagar, Hanaa Y.; Emara, S.A; Nada, M.; Abdel-Megeid, Nazema S.

doi:10.21608/jcvr.2024.384958

Prenatal Development of Rabbit Cerebellum

Document Type : Original Article

Authors

10.21608/jcvr.2024.384958

Abstract

The present study's purpose was to give an overview of the rabbit cerebellum's
prenatal developmental stages. Forty embryos of prenatal ages (E10, E15, E17,
E20, E25, E25 and E30) were obtained from the rabbit. The cerebellum
primordium appeared on day 10 (E10). At E25 the cerebellar primordium formed
from the neuroepithelium, mantle layer and marginal layer. The peripheral layer
of neuroepithelium transformed to external granular layer (EGL). This EGL is
termed as second germinal layer. The EGL molecular development was a distinct
structure in the developing cerebellum that afterward disappeared. On day 30
prenatal embryos of rabbits, the cerebellum was not fully differentiated. The
cerebellar cortex consisted of external granular and internal granular layers. An
extended process that takes place during prenatal and postnatal life gives the
mature cerebellum its ultimate structure. In the current study, the rabbit
cerebellum's prenatal development and age-related histogenesis were connected.

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