Synthesis, Characterization of Zinc Complex and Effect of Gamma Irradiation on Biological Activities

Aly, Samar A.; Hassan, Safaa S.; Rizk, Nashwa M.H.; Salem, Mohamed F.; Hosny, Shimaa; Alshater, Heba; Ali, Aya

doi:10.21608/jcvr.2025.459069

Synthesis, Characterization of Zinc Complex and Effect of Gamma Irradiation on Biological Activities

Document Type : Original Article

Authors

10.21608/jcvr.2025.459069

Abstract

A new zinc(II) complex incorporating a hydrazone ligand derived from a pyran scaffold was synthesized and subjected to comprehensive physicochemical and spectral analysis. The complex exhibited a 1:1 metal-to-ligand ratio, with coordination occurring via azomethine nitrogen and carbonyl oxygen atoms, as confirmed by FT-IR, ESI-MS, UV–Vis spectroscopy, and elemental data. Thermogravimetric analysis indicated stability up to 215 °C, followed by successive decomposition stages. The biological behavior of the free ligand and its Zn(II) complex was assessed against bacterial strains and the MCF7 human breast cancer cell line. Notably, complexation with zinc enhanced both antibacterial and cytotoxic effects, which were further intensified after exposure to gamma irradiation. Structural modifications induced by irradiation were associated with improved biological responses. These findings suggest the feasibility of using radiation to fine-tune the bioactivity of metal-based therapeutic candidates, particularly those derived from hydrazone scaffolds.

Keywords