Ameliorative Effect of Commiphora Myrrha Against Oxidative Stress Induced by High Fat Diet in Rats

Document Type : Original Article

Authors

1 Biochemistry, veterinary medicine University of Sadat city

2 Department of Surgery, Faculty of Veterinary Medicine, University of Sadat City, Egypt

3 Department of Biochemistry, Faculty of Veterinary Medicine, Menoufia University, Egypt

Abstract

ObesityObesityObesityObesityObesityObesityObesity is a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association a cause of health problems due to its strong association to many many many many disorders'disorders'disorders'disorders' disorders'disorders' disorders' incidence incidence incidence incidence incidence incidence incidence incidence incidence incidence as renal diseaseas renal diseaseas renal diseaseas renal disease as renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal diseaseas renal disease. This paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimating This paper aims at estimatingThis paper aims at estimatingThis paper aims at estimating This paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimating This paper aims at estimatingThis paper aims at estimatingThis paper aims at estimatingThis paper aims at estimating the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of the evolution of oxidative stress oxidative stressoxidative stressoxidative stressoxidative stressoxidative stressoxidative stressoxidative stressoxidative stressoxidative stressoxidative stressoxidative stress oxidative stressoxidative stress in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of in response to high fat diet (HFD) and the effect of Commiphora ommiphora ommiphora ommiphora ommiphora ommiphora Myrrha resinyrrha resin yrrha resinyrrha resinyrrha resinyrrha resin yrrha resinyrrha resinyrrha resin ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract ethanolic extract (CME(CME(CME(CMEE) on on renal MDA renal MDArenal MDArenal MDArenal MDArenal MDArenal MDArenal MDA, glutathione, glutathione, glutathione, glutathione, glutathione, glutathione, glutathione, glutathione, glutathione, glutathione, glutathione , glutathione reductase reductasereductasereductasereductasereductasereductasereductase (GR ) activityactivityactivityactivityactivityactivityactivityactivity in kidney and histopathological alterations renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissue in kidney and histopathological alterations renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissue in kidney and histopathological alterations renal tissue in kidney and histopathological alterations renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissue in kidney and histopathological alterations renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissue in kidney and histopathological alterations renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissue in kidney and histopathological alterations renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissuein kidney and histopathological alterations in renal tissue. Fifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister ifty adult Wister albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats albino male rats were weighwere weighwere weigh were weighwere weighwere weighwere weighwere weighwere weighed from 100from 100 from 100from 100from 100-120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each 120 g and assigned into five groups each of 10 rats. of 10 rats. of 10 rats. of 10 rats. of 10 rats. of 10 rats. of 10 rats. of 10 rats. of 10 rats. of 10 rats. Rats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Cr ats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Cr ats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Cr ats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Crats were fed on a basal diet for 14 weeks (Cr groupgroup group). Rats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on ats were fed on a basal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administrated basal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administratedbasal diet and administrated basal diet and administratedbasal diet and administratedbasal diet and administrated orally orallyorallyorally CMECMECMEE at doseat doseat doseat doseat dose at dose of 500 mg/kg for 14 weeks mg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeks mg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeksmg/kg for 14 weeks (CM (CM (CM (CM group)group) group)group). Rats were fed oats were fed oats were fed oats were fed oats were fed oats were fed oats were fed o ats were fed oats were fed oats were fed oats were fed oats were fed oats were fed on HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeks n HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeksn HFD for 14 weeks (HFD group)(HFD group)(HFD group)(HFD group)(HFD group)(HFD group)(HFD group) (HFD group)(HFD group). Rats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and ats were fed on HFD and orally administration of CME orally administration of CMEorally administration of CMEorally administration of CMEorally administration of CMEorally administration of CMEorally administration of CMEorally administration of CME orally administration of CMEorally administration of CMEorally administration of CMEorally administration of CMEorally administration of CME orally administration of CMEorally administration of CMEorally administration of CME orally administration of CMEorally administration of CME orally administration of CMEorally administration of CMEorally administration of CMEorally administration of CMEE at doseat doseat doseat doseat dose at dose of 500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks 500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks 500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks500 mg/kg for 14 weeks (HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group)(HFD + CM group) (HFD + CM group)(HFD + CM group). Rats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and ats were fed on HFD for 8 weeks then stop and a basal dietbasal dietbasal dietbasal dietbasal dietbasal dietbasal dietbasal dietbasal dietbasal diet with oral with oral with oral with oral with oral with oral with oral with oral administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose administration of CMEE at dose 500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight 500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight 500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight500 mg/kg bodyweight for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks for another 6 weeks (HFD HFD HFD HFD thenthenthenthen normal diet +CM groupnormal diet +CM group normal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM groupnormal diet +CM group normal diet +CM group). ). ). MDAMDAMDA level level level level level level and and and and GR activityGR activityGR activityGR activityGR activityGR activityGR activityGR activityGR activityGR activityGR activity were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with were estimated with histopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissue histopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissue histopathological examination of renal tissue histopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissue histopathological examination of renal tissue histopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissue histopathological examination of renal tissuehistopathological examination of renal tissue histopathological examination of renal tissuehistopathological examination of renal tissue histopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissuehistopathological examination of renal tissue of rats. of rats.of rats. of rats.of rats.of rats. A significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase in A significant increase inA significant increase inA significant increase inA significant increase inA significant increase inA significant increase in MDA MDA MDA MDA levellevellevellevellevel and and and and a significantsignificantsignificantsignificantsignificantsignificantsignificantsignificantsignificantsignificantsignificant decreasedecreasedecreasedecrease decreasedecreasedecrease of of GR activityactivityactivityactivityactivityactivityactivityactivity in thethethe HFD ratsHFD ratsHFD ratsHFD ratsHFD rats HFD ratsHFD rats. Administration of dministration of dministration of dministration of dministration of dministration of dministration of dministration of dministration of dministration of dministration of dministration of dministration of CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD CMEE to HFD rats rats rats rats in groupin groupin groupin groupin group in groups IV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level IV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level andIV and V decreased significantly MDA level increaseincreaseincreaseincrease increaseincreaseincreased significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantlyd significantly activityactivityactivityactivityactivityactivityactivityactivity of GR en of GR enof GR enof GR enof GR enof GR enof GR enzymezymezyme as compared with the HFD groupcompared with the HFD group compared with the HFD groupcompared with the HFD group compared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD groupcompared with the HFD group compared with the HFD group. MoreoverMoreover Moreover MoreoverMoreover, the GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both group the GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both group the GR activity reached to normal level in both groupthe GR activity reached to normal level in both group the GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both group the GR activity reached to normal level in both groupthe GR activity reached to normal level in both groupthe GR activity reached to normal level in both group the GR activity reached to normal level in both groups compared compared compared compared compared compared in the the the the control group. control group. control group. control group. control group. control group. control group. control group. control group. control group. HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to HFD induced obesity correlated to kidneykidneykidneykidneykidneykidney disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the disorders. CME had the ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve ability to improve oxidative stress induced by HFD oxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFD oxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFDoxidative stress induced by HFD.

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Main Subjects