Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats

Salamah, Soaad; Attia, Taha; El-Hewaity, Mohamed; El Hanbaly, Saber; El-Gendy, Hanem

doi:10.21608/jcvr.2020.90231

Pharmacokinetic of Cefquinome After Single I.V Administration Alone and Concurrent with Meloxicam in Goats

Document Type : Original Article

Authors

¹ Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt.

² Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Egypt.

10.21608/jcvr.2020.90231

Abstract

The active profile of cefquinome in goats was concentrated after single intravenous organization of cefquinome alone and single intravenous organizations in goats pretreated with meloxicam at a portion of 2 mg/kg b.wt. Serum groupings of cefquinome were dictated by utilizing superior fluid chromatography (HPLC). Following compartmental examination, a two-compartment open model best portrayed the fixation time information of cefquinome after i.v. organization The outcomes uncovered that after a solitary intravenous injection, cefquinome was distinguished till 24 hours, dispersion half-life (t1/2á) of cefquinome was 0.281 ± 0.055 h, elimination half-life (t1/2â) was of 5.46 ± 0.22 h and clearance (CL) was 0.04 ± 0.0013 (L/kg/h), volume of distribution at steady state (Vdss) was 0.31 ± 0.018 (L/kg). Following a single intravenous injection pretreated with meloxicam, distribution half-life (t1/2á) was 0.227 ± 0.07 h, elimination half-life (t1/2â) was of 3.63 ± 0.055 h and clearance (CL) was 0.056 ± 0.0022 (L/kg/h), volume of distribution at steady state (Vdss) was 0.296 ± 0.0163 (L/kg). From this examination, we inferred that organization of meloxicam (0.2 mg/kg b.wt.) may be successfully co-administrated with cefquinome (2 mg/kg b.wt.) for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect on the kinetics of cefquinome.

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